Research and Clinical Trials

Researchers within the Division of Transplantation at the University of Maryland Medical Center areDr. Barth in lab committed to investigating new ways to advance the science of transplantation and ensure better futures for patients in need of transplant or for those who are already living with organ transplants.

The research within the Division of Transplantation falls into several categories: 

  • Inducing tolerance - teaching the body to accept a foreign graft, such as a transplanted organ, without rejection and with limited or no immunosuppression. 
  • Immunosuppression medications and medication management - testing the latest medications or combinations of medications to prevent rejection while reducing the "pill burden" on patients and creating protocols that demonstrate long-term success with fewer side effects.
  • Increasing the number of available donor organs - through tissue regeneration and systematic sourcing of available organs.
  • Advancements in surgical technique - use of new operative tools, materials and techniques, including the single-incision laparoscopic surgery used on living kidney donors. 
    • See paper published on single-port donor nephrectomy through belly button and watch video. 
  • Using bone marrow-derived stem cells to decrease rejection - could help eliminate need for immunosuppression in all types of organ recipients.
  • Bridge-to-transplant technology - medical devices used to help patients who are in need of transplant but either not at the top of the wait list or without an available donor organ. 

Clinical Trials

Actively Funded DOD Grants

Adult Tissue-Derived Stem Cells and Tolerance Induction in Nonhuman Primates for Vascularized Composite Allograft Transplantation
Congressionally Directed Medical Research Programs (CDMRP)

Vascularized Bone Marrow Regulates Alloresponses to Vascularized Composite Allografts
Dept. of Defense – AFIRM II

Upregulation of bone marrow compartment mediated immunomodulation for vascularized composite allografts

Congressionally Directed Medical Research Programs
Restorative Transplantation Research Cooperative Agreement